Early, but real: an antibody clears the immune attack behind a rare kidney disease

Primary membranous nephropathy is a rare disease in which the immune system attacks the kidneys' filters, leaking protein and threatening kidney failure. At Kidney Week in Denver, Climb Bio reported the first Phase 2 results for budoprutug, an antibody that depletes the B cells driving the attack: at the lowest dose tested, patients at 12 weeks showed B-cell depletion, falling disease antibodies and immunologic remission, matching earlier results, and the treatment was generally well tolerated. A separate case described a patient with a related disease staying in remission for three years without steroids. Larger cohorts are still being tested.

SDG 3 · Good health and well-being — Mechanism: tech innovation